B-RAF with PLX4032

B-RAF with PLX4032
PLX4032 is a newly synthesized drug that is being used to treat malignant melanoma with a specific mutation. The mutation is B-RAF^(V600E). This drug is highly selective for this mutation and will not bind to wild type B-RAF.

 PLX 4032 ATP Wild-Type B-RAF V600E Mutation H-Bond Interaction Asp594 and PLX4032 Superposition overview Superposition close up Superposition active site